IGF1R (N-term) Peptide
产品名称： IGF1R (N-term) Peptide
英文名称： IGF1R (N-term) Peptide
产品编号： P2678
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of IGF1R.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human IGF1R.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The role of Shc and insulin-like growth factor 1 receptor in mediating the translocation of estrogen receptor alpha to the plasma membrane.
Song RX, Barnes CJ, Zhang Z, Bao Y, Kumar R, Santen RJ.Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2076-81. Epub 2004 Feb 5.
- 2.
- Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells.
Lu Y, Zi X, Zhao Y, Pollak M.Biochem Biophys Res Commun. 2004 Jan 16;313(3):709-15.
- 3.
- PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells.
Zhao H, Dupont J, Yakar S, Karas M, LeRoith D.Oncogene. 2004 Jan 22;23(3):786-94.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of SK-BR-3 cell lysate (35 ug/lane) with IGF1R polyclonal antibody (Cat # PAB3055).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with IGF1R polyclonal antibody (Cat # PAB3055) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 3480
- Protein Accession#:
- P08069
- Gene Name:
- IGF1R
- Gene Alias:
- CD221,IGFIR,JTK13,MGC142170,MGC142172,MGC18216
- Gene Description:
- insulin-like growth factor 1 receptor
- Omim ID:
- 147370
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
- Other Designations:
- soluble IGF1R variant 1,soluble IGF1R variant 2
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