Anti-CTCF Polyclonal Antibody
产品名称: Anti-CTCF Polyclonal Antibody
英文名称: Anti-CTCF Polyclonal Antibody
产品编号: K002202P
产品价格: null
产品产地: 北京
品牌商标: Solarbio
更新时间: 2025-01-14T14:04:38
使用范围:
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
- 电话 : 178****1073 点击查看
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- 邮箱 : 3193328036@qq.com
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Anti-CTCF Polyclonal Antibody
品牌:solarbio | 货号:K002202P
英文名称 | Anti-CTCF Polyclonal Antibody |
---|---|
别名 | MRD21 |
应用 | WB IF IP ChIP |
稀释比例 | WB 1:500-2000. IF 1:50-200. IP 1:50-100. ChIP 1:50-200. |
交叉反应 | Human Mouse Rat Monkey |
蛋白分子量 | 83kDa |
Gene ID | 10664 |
保存 | Store at -20°C. Avoid freeze / thaw cycles. |
储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
纯化方法 | Affinity purification |
亚型 | IgG |
免疫原 | Recombinant protein of human CTCF |
性状 | 液体 |
Public Immunogen Range | Recombinant protein of human CTCF |
Subcellular Locations | Chromosome Nucleus centromere nucleoplasm |
Swiss Prot | P49711 |
克隆类型 | Polyclonal Antibody |
背景资料 | This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |