Anti-SFN Polyclonal Antibody
产品名称： Anti-SFN Polyclonal Antibody
英文名称： Anti-SFN Polyclonal Antibody
产品编号： K001908P
产品价格： null
产品产地： 北京
品牌商标： Solarbio
更新时间： 2025-01-14T14:04:38
使用范围：
北京索莱宝科技有限公司
- 联系人 : 索莱宝-龚思雨
- 地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
- 邮编 : 101102
- 所在区域 : 北京
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Anti-SFN Polyclonal Antibody
品牌：solarbio | 货号：K001908P
英文名称 Anti-SFN Polyclonal Antibody 别名 YWHAS 应用 WB IHC IF 稀释比例 WB 1:500-2000. IHC 1:50-200. IF 1:50-200. 交叉反应 Human Mouse Rat 蛋白分子量 28kDa Gene ID 2810 保存 Store at -20°C. Avoid freeze / thaw cycles. 储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. 纯化方法 Affinity purification 亚型 IgG 免疫原 Recombinant protein of human SFN 性状 液体 Public Immunogen Range Recombinant protein of human SFN Subcellular Locations Cytoplasm Nucleus Secreted Swiss Prot P31947 克隆类型 Polyclonal Antibody 背景资料 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events.