Anti-CD274 Polyclonal Antibody

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000354P-50ul	solarbio	50ul	960.00元
K000354P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-CD274 Polyclonal Antibody
别名	B7-H;B7H1;PD-L1;PDCD1L1;PDCD1LG1;PDL1
应用	WB IF
稀释比例	WB 1:500-2000. IF 1:50-200.
交叉反应	Human Mouse Rat
蛋白分子量	33kDa
Gene ID	29126
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human CD274
性状	液体
Public Immunogen Range	Recombinant protein of human CD274
Subcellular Locations	Cell membrane Endomembrane system Single-pass type I membrane protein
Swiss Prot	Q9NZQ7
克隆类型	Polyclonal Antibody
背景资料	This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.