Anti-PML Polyclonal Antibody

商品货号：	商品品牌：	规格	基本售价：	选择规格
K002372P-50ul	solarbio	50ul	960.00元
K002372P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-PML Polyclonal Antibody
别名	MYL;PP8675;RNF71;TRIM19
应用	WB IHC IF
稀释比例	WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应	Human Mouse
蛋白分子量	98kDa
Gene ID	5371
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human PML
性状	液体
Public Immunogen Range	Recombinant protein of human PML
Subcellular Locations	Cytoplasm Cytoplasmic side Early endosome membrane Endoplasmic reticulum membrane Nucleus PML body Peripheral membrane protein nucleolus nucleoplasm
Swiss Prot	P29590
克隆类型	Polyclonal Antibody
背景资料	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.